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产品介绍
产品信息
克隆类别
单抗
浓度
Lot specific,typically between 4-11 mg/ml
Product Details
The MFL3 monoclonal antibody reacts with mouse Fas Ligand (FasL) also known as CD178, CD95 Ligand, and TNFSF6. FasL is a 40 kDa type II transmembrane glycoprotein and a member of the TNF superfamily. FasL is expressed on activated T cells and in spleen, testis, and eye. Upon binding to its receptor CD95 (Fas) FasL induces apoptotic cell death to maintain peripheral tolerance. Some tumors over-express FasL and induce the apoptosis of infiltrating lymphocytes, allowing the tumor to escape the effects of an immune response. CD178/CD95 interactions are also thought to play a role in the proliferation of CD8+ cells and neutrophil extravasation, chemotaxis and survival. The MFL3 antibody has been reported to block CD178/CD95 induced apoptosis.Specifications
| Isotype | Armenian hamster IgG |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb polyclonal Armenian hamster IgG |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | BHK cells expressing B6 mouse FasL |
| Reported Applications | in vivo FasL blockade In vitro FasL blockade Functional assay Immunohistochemistry (paraffin) Flow Cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 μM filtered |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_2819046 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
抗凋亡相关因子配体抗体
应用
实验应用
false
反应种属
mouse
背景
研究领域
Apoptosis, Cancer Biology, Immunology
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危险品化学品经营许可证(不带存储) 许可证编号：沪(杨)应急管危经许[2022]202944(QY) 
营业执照(三证合一)