FBXO3

Recombinant protein corresponding to aa276-376 from human F-box only protein 3.

Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence. Other applications not tested.

Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.

IgG

Polyclonal

Purified by Protein G affinity chromatography.

Suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence. Other applications not tested.

Western Blot: 1:200-1:5000 Immunohistochemistry: 1:20-1:200 Immunofluorescence: 1:50-1:200 Optimal dilutions to be determined by the researcher.

Rabbit

Hu Mo

Recognizes human FBXO3. Species Crossreactivity: mouse

F-box only protein 3, FBXO3, FBX3

Q9UK99