FH535

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FH535

品牌： Absin

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参数

分子式：

C₁₃H₁₀Cl₂N₂O₄S

分子量：

361.2

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产品介绍

产品信息

抗原名称

Wnt/β-catenin；PPARγ；PPARδ

商品描述

FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.

分子量

361.2

纯度

98%

可溶性

DMSO ：72mg/ml(199.34 mM)

外观

Yellow solid

In vitro(体外研究)

FH535 antagonizes β-Catenin/Tcf–mediated transcription, and inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/β-catenin pathway. FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in β-catenin and EGR-1 signaling. FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines.

In vivo(体内研究)

FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.

背景

别名

FH 535; FH-535

分子式

C₁₃H₁₀Cl₂N₂O₄S

CAS号

108409-83-2

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs810355-5mg

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