HPV16 E7 (NM2)

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HPV16 E7抗体(NM2)是小鼠单克隆IgG2a κ, 在26篇文献中引用，规格为200 µg/ml免疫HPV16物种的E7的氨基酸35-56HPV16 E7 抗体 (NM2) 推荐用于WB, IP 和 IF，检测HPV-16 来源的 E7 GST抗-HPV16 E7 抗体 (NM2) 可偶联 琼脂糖 用于 IP; HRP 用于 WB, IHC(P) 和 ELISA; 还可偶联 藻红蛋白 或者 FITC 用于 IF, IHC(P) 和 FCM还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统关于如何获取HPV16 E7 (NM2): sc-65711的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。m-IgG Fc BP-HRP and m-IgG2a BP-HRP 是 HPV16 E7 Antibody (NM2) for WB首选应用二抗。这些试剂现在以套装形式提供HPV16 E7 Antibody (NM2) (见下方订购信息). 查看产品引用文献(26) The HPV E7 proteins are small zinc-binding phosphoproteins that are localized in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumor suppressor protein pRb. This sequence is also present in SV40 and polyoma large T antigens. The high risk HPV E7 proteins (e.g. HPV16 E7 and HPV18 E7) have an approximately ten-fold higher affinity for pRb protein than the low risk HPV E7 proteins (e.g. HPV6 E7). Association of the E7 protein with pRb promotes cell proliferation by the same mechanism as the E1A proteins of adenoviruses and SV40 large T antigen. Research has shown that E7 promotes degradation of Rb family proteins rather than simply inhibiting their function by complex formation. The CR2 region also contains the casein kinase II phosphorylation site (residues 31 and 32). HPV16 and 18 are strongly associated with cervical, vaginal and vulvar malignancies.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USALI-COR® and Odyssey® are registered trademarks of LI-CO

Replacement monoclonal antibody for: sc-1587, sc-1588.

人乳头瘤病毒16型E7蛋白抗体、磷酸缓冲盐溶液