ICAM-1/CD54 Fc Chimera Protein, Human
1/2

ICAM-1/CD54 Fc Chimera Protein, Human

分享
品牌: UA BIOSCIENCE
pdf 下载产品说明书
用小程序,查商品更便捷
收藏
对比对比
咨询咨询
    分子量:

    49-72kDa (Reducing)

    49-72kDa (Reducing)

    纯度:

    >95% by SDS-PAGE

    >95% by SDS-PAGE

    产品介绍
    产品信息
    耦联标记
    Unconjugated
    氨基酸序列

    Gln28-Glu480, with C-terminal Human IgG1 Fc

    QTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

    分子量

    49-72kDa (Reducing)

    纯度

    >95% by SDS-PAGE

    内毒素水平
    <0.1EU/μg
    性状
    Lyophilized powder
    表达系统
    HEK293
    缓冲体系
    PBS, pH7.4
    标签
    Fc Tag
    种属
    Human
    电泳JSON
    [{"imgUrl":"https://univ-njua.oss-cn-shanghai.aliyuncs.com/prod/202211/96a94cf8a45b41719dc8e033b7b97d76.png","description":"2μg (R: reducing conditions, N: non-reducing conditions)."}]
    背景
    别名
    BB2, CD54 antigen, CD54, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1 (CD54)
    背景

    ICAM-1 is a cell-surface glycoprotein and a member of the immunoglobulin (Ig) protein superfamily. ICAM-1 mediates the interaction between keratinocytes and leukocytes. ICAM-1 facilitates a variety of both afferent and efferent immune responses that require intercellular contact and collaboration, including T helper responses, T-dependent B cell responses, antigen-induced T cell proliferation, cell-mediated cytotoxicity, and the binding of leukocytes to vascular endothelium prior to extravasation into inflamed tissue. Pro-inflammatory cytokines interferon-γ and TNF-α stimulate the expression of keratinocyte ICAM-1 and this up-regulation is blocked both in vivo and in vitro if keratinocytes are irradiated with UVB prior to cytokine treatment. In contrast, ICAM-2 is expressed primarily on endothelium and leukocytes (except neutrophils), and its expression generally is not responsive to cytokines. ICAM-3 predominates on thymocytes and resting lymphocytes, which are low in ICAM-1. When neutrophils are activated, they shed the majority of their ICAM-3 into the medium by proteolytic cleavage. In some reports, the expression of ICAM-1 has been positively correlated with a more aggressive tumor phenotype and metastatic potential. For instance, the invasiveness of breast cancer cells has been positively correlated with the expression of ICAM-1. Also, it has been suggested that an ICAM-1–ICAM-1 homophilic interaction between breast cancer cells and mesenchymal stem cells in bone marrow mediates the metastatic expansion of cancer cells, displacing hematopoietic stem cells from their niche.

    制备和贮存
    溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    保存方式
    • 12 months from date of receipt, -20 to -70 °C as supplied. 
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
    • 1 week, 2 to 8 °C under sterile conditions after reconstitution.  
    • Please avoid repeated freeze-thaw cycles.

    参考图片

    2μg (R: reducing conditions, N: non-reducing conditions).

    Immobilized ICAM-1/CD54 Fc Chimera, Human (Cat. No. UA010156) at 2.0μg/mL (100μL/well) can bind ICAM-1/CD54 Recombinant Rabbit mAb (S-906-48) (S-1233-25) (Cat. No. S0B0795)  with EC50 of 1.62-2.20ng/mL.

    声明 :本官网所有报价均为常温或者蓝冰运输价格,如有产品需要干冰运输,需另外加收干冰运输费。
    货号:
    UA010156-100ug
    一键复制
    询价
    优宁维现货
    100μg
    500μg
    选择数量
    当前规格1件起购 
    配送至
    预计2-5个工作日送达,快递: 免运费,若需干冰额外收费