CD278/ICOS Recombinant Rabbit mAb (SDT-R104)

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CD278/ICOS Recombinant Rabbit mAb (SDT-R104)

品牌： STARTER

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参数

反应种属：

来源宿主：

Rabbit

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产品介绍

产品信息

纯化方式

Protein A

抗原名称

CD278/ICOS

宿主

Rabbit

免疫原

N/A

克隆号

SDT-R104

浓度

0.5 mg/ml

性状

Liquid

缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

产品类型

Rabbit mAb

应用

实验应用

IHC-P

反应种属

稀释度

IHC-P

1:500

背景

别名

Inducible T-cell costimulator, AILIM

背景

Inducible T cell costimulatory factor (ICOS, cluster of differentiation, CD278) is an activated costimulatory immune checkpoint expressed on T cells. Its ligand ICOSL was expressed in antigen-presenting cells and somatic cells (including tumor cells in the tumor microenvironment) [PMID: 28713380, PMID: 12800259]. As one of the most common targeted immune checkpoints, ICOS is considered a possible way to develop new immunotherapy [PMID: 29544515]. Some clinical studies shown that blocking ICOS alone can inhibit tumor growth and proliferation, as well as TIGIT, CTLA4, and PD-1 [PMID: 30232519, PMID: 28803728].

细胞定位

Secreted、Cell membrane

制备和贮存

保存方式

12 months from date of receipt / reconstitution, -20 °C as supplied

数据库链接

Accession

Q9Y6W8

参考图片

IHC shows positive staining in paraffin-embedded human thymus. Anti-CD278/ICOS antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

IHC shows positive staining in paraffin-embedded human tonsil. Anti-CD278/ICOS antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

Negative control: IHC shows negative staining in paraffin-embedded human kidney. Anti-CD278/ICOS antibody was used at 1/500 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.

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货号：

S0B2154-10ul

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10μl

500μl

25 μl

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1 ml

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