IFIT3 (E8G5Y) Rabbit mAb

IFIT3 (Interferon-induced protein with tetratricopeptide repeats 3; Retinoic acid-induced gene G protein (RIG-G)) is part of the IFIT family of interferon-stimulating genes known for their antiviral properties (1,2). IFIT3 is widely expressed in T cells, B cells, plasmacytoid and myeloid dendritic cells, neurons, and kidney cells (3,4). In response to RNA viral infection, IFIT3 regulates IRF3 activation through interaction with TBK1 and MAVS on the mitochondrion (5). IFIT3 also interacts with IFIT1, leading to inhibitory activity against viral RNA lacking the 2′-O-methylation in the cap structure (6). 1.Yu, M. et al. (1997) Proc Natl Acad Sci U S A 94, 7406-11. 2.Xiao, S. et al. (2006) Proc Natl Acad Sci U S A 103, 16448-53. 3.Fensterl, V. et al. (2008) J Virol 82, 11045-53. 4.Wacher, C. et al. (2007) J Virol 81, 860-71. 5.Liu, X.Y. et al. (2011) J Immunol 187, 2559-68. 6.Johnson, B. et al. (2018) Immunity 48, 487-499.e5.