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IgG1 Fc Protein, Human

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IgG1 Fc Protein, Human

品牌： UA BIOSCIENCE

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参数

分子量：

32-34 KDa(Reducing)

纯度：

＞95%, by SDS-PAGE under reducing conditions

产品介绍

产品信息

耦联标记

Unconjugated

氨基酸序列

EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

分子量

32-34 KDa(Reducing)

纯度

＞95%, by SDS-PAGE under reducing conditions

内毒素水平

<0.1EU/μg

性状

Lyophilized powder

表达系统

HEK293

缓冲体系

PBS, pH7.4, 5% trehalose

标签

Fc Tag

种属

Human

电泳JSON

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背景

别名

IgG1 Fc;g gamma-1 chain C region,IGHG1

背景

Fc is a crystallizable fragment composed of the carboxyl terminal of two kinds of immunoglobulin heavy chain, which is connected to each other by disulfide bond. The Fc fragment contains the carboxyl terminal part of the heavy chain fixation region, which is responsible for the effect function of immunoglobulin (complement fixation, binding to the cell membrane through Fc receptors, and placental transport). It is reported that IgG1 Fc, as a potential anti-inflammatory drug, plays a new role in the treatment of human autoimmune diseases.

制备和贮存

溶解方法

Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

保存方式

· 12 months from date of receipt, -20 to -70 °C as supplied.
· 6 months, -20 to -70 °C under sterile conditions after reconstitution.
· 1 week, 2 to 8 °C under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

数据库链接

Accession

P01857-1

参考图片

Anti-His antibody Immobilized on CM5 Chip captured CD16b(NA1) His Tag, Human (Cat. No. UA020006), can bind IgG1-Fc (UA050001) with an affinity constant of 9.237 μM as determined in SPR assay (Biacore T200).

IgG1 Fc, Human ，2μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

Immobilized Biotinylated FcγRIIa/CD32a(H167) Avi&His Tag, Human (Cat. No. UA010430) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind IgG1 Fc, Human (Cat. No. UA050001) with EC50 of 0.38-0.44 μg/ml.

Immobilized Biotinylated FcγRIIA/CD32a(R167) His&Avi Tag, Human(Cat. No. UA010748) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind IgG1 Fc, Human (Cat. No. UA050001) with EC50 of 0.37-0.48 μg/ml.

Immobilized Biotinylated Fc γ RIIIa/CD16a(V176) Avi&His Tag Protein, Human (Cat. No. UA010763) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind IgG1 Fc Protein, Human (Cat. No. UA050001) with EC50 of 0.46-1.14μg/ml.

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货号：

UA050001-50μg

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