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12 kDa(Reducing)
12 kDa(Reducing)
>95% by SDS-PAGE
>95% by SDS-PAGE
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12 kDa(Reducing)
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>95% by SDS-PAGE
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Interleukin-15 (IL-15), a cytokine discovered in 1994, supports the homeostasis of cytotoxic immune cells, exhibits a broad biological activity. IL-15 stimulate the proliferation of activated T cells as well as to facilitate the induction of cytotoxic T-lymphocytes (like CD8+), and the generation, proliferation, and activation of NK cells. Therefore, IL-15 is applied to the rapidly expanding cancer immunotherapy field combining with other agents, i.e., checkpoint inhibitors, monoclonal antibodies, chemotherapy, radiation, and chimeric antigen receptor T (CAR-T) cells, in order to target multiple mechanisms and enhance the immune response against tumors, which provides advantages to control and treat cancers.
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Reconstitute at 0.1-1mg/ml according to the size in ultrapure water after rapid centrifugation.
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· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
参考图片
The EC50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 was found to be <0.2ng/ml.
1μg (N: non-reducing condition, R: reducing condition).
Anti-His antibody Immobilized on CM5 Chip captured IL-2R beta/CD122 His Tag, Human (Cat. No. UA010372), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 19.04 nM as determined in SPR assay.
Protein A Chip captured IL-15R alpha/CD215 Fc Chimera, Human (Cat. No. UA010309), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 4.35 nM as determined in SPR assay.