IL-15 Protein, Human
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IL-15 Protein, Human

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品牌: UA BIOSCIENCE
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    分子量:

    12 kDa(Reducing)

    12 kDa(Reducing)

    纯度:

    >95% by SDS-PAGE

    >95% by SDS-PAGE

    产品介绍
    产品信息
    耦联标记
    Unconjugated
    氨基酸序列
    Asn49-Ser162
    分子量

    12 kDa(Reducing)

    生物活性
    <1ng/ml
    纯度

    >95% by SDS-PAGE

    内毒素水平
    <1EU/μg
    性状
    Lyophilized powder
    表达系统
    E.coli
    缓冲体系
    PBS, pH7.4
    标签
    No Tag
    种属
    Human
    电泳JSON
    [{"imgUrl":"https://univ-njua.oss-cn-shanghai.aliyuncs.com/prod/202208/6feabc8d933b42329fab46096ce8e473.jpg","description":"1μg (N: non-reducing condition, R: reducing condition)."}]
    背景
    背景

    Interleukin-15 (IL-15), a cytokine discovered in 1994, supports the homeostasis of cytotoxic immune cells, exhibits a broad biological activity. IL-15 stimulate the proliferation of activated T cells as well as to facilitate the induction of cytotoxic T-lymphocytes (like CD8+), and the generation, proliferation, and activation of NK cells. Therefore, IL-15 is applied to the rapidly expanding cancer immunotherapy field combining with other agents, i.e., checkpoint inhibitors, monoclonal antibodies, chemotherapy, radiation, and chimeric antigen receptor T (CAR-T) cells, in order to target multiple mechanisms and enhance the immune response against tumors, which provides advantages to control and treat cancers.

    制备和贮存
    溶解方法

    Reconstitute at 0.1-1mg/ml according to the size in ultrapure water after rapid centrifugation.

    保存方式

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

    数据库链接
    Accession

    参考图片

    The EC50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 was found to be <0.2ng/ml.

    1μg (N: non-reducing condition, R: reducing condition).

    Anti-His antibody Immobilized on CM5 Chip captured IL-2R beta/CD122 His Tag, Human (Cat. No. UA010372), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 19.04 nM as determined in SPR assay.

    Protein A Chip captured IL-15R alpha/CD215 Fc Chimera, Human (Cat. No. UA010309), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 4.35 nM as determined in SPR assay.

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    货号:
    UA040010-50μg
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