IL-2 Protein, Rat

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IL-2 Protein, Rat

品牌： UA BIOSCIENCE

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参数

分子量：

16kDa (Reducing)

纯度：

＞95% by SDS-PAGE&RP-HPLC

产品介绍

产品信息

耦联标记

Unconjugated

氨基酸序列

Ala21-Gln155

分子量

16kDa (Reducing)

生物活性

<0.2 ng/ml

纯度

＞95% by SDS-PAGE&RP-HPLC

内毒素水平

<0.1EU/μg

性状

Lyophilized Powder

表达系统

E.coli

缓冲体系

50mM NaAc,150mM NaCl,pH5.0

标签

No Tag

种属

Rat

电泳JSON

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2μg (R: reducing condition, N: non-reducing condition).

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背景

别名

TCGF，IL2，Interleukin 2，T Cell Growth Factor，Aldesleukin，IL-2，TCGF，Involved In Regulation Of T-Cell Clonal Expansion，Interleukin-2，Lymphokine

背景

Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL2 shares 56% and 73% aa sequence identity with human and rat IL2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL2 may be a key cytokine in the natural suppression of autoimmunity.

制备和贮存

溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

保存方式

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

文献

1.Pol, J. G. , Caudana, P. , Paillet, J. , Piaggio, E. , & Kroemer, G. . (2020).

2.Effects of interleukin-2 in immunostimulation and immunosuppression. The Journal of Experimental Medicine(1), 217.

3.Kolios, A. G., Tsokos, G. C., & Klatzmann, D. (2021). Interleukin-2 and regulatory T cells in rheumatic diseases. Nature Reviews Rheumatology, 17(12), 749-766. Zhang, Y., & Su, J. (2023).

4.Interleukin-2 family cytokines: An overview of genes, expression, signaling and functional roles in teleost. Developmental & Comparative Immunology, 104645.

数据库链接

Accession

P17108

参考图片

2μg (R: reducing condition, N: non-reducing condition).

Measured in a cell proliferation assay using CTLL2 cells, the EC50 for this effect is less than 0.2ng/ml.

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货号：

UA040229-1mg

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