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IL-6 Protein, Human
IL-6 Protein, Human
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IL-6 Protein, Human

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    分子量：
    21kDa
    21kDa
    纯度：
    >95% by SDS-PAGE
    >95% by SDS-PAGE
    产品介绍
    产品信息
    耦联标记
    Unconjugated
    氨基酸序列
    Val30-Met212
    分子量
    21kDa
    生物活性
    <0.2ng/ml
    纯度
    >95% by SDS-PAGE
    内毒素水平
    <1EU/μg
    性状
    Lyophilized powder
    表达系统
    E.coli
    缓冲体系
    20mM Tris, 100mM NaCl, pH8.0
    标签
    No Tag
    种属
    Human
    电泳JSON
    [{"imgUrl":"https://univ-njua.oss-cn-shanghai.aliyuncs.com/prod/202302/5d321fe297e54da9af4ead94459e21fe.png","description":"1μg (R:reducingcondition;N:non-reducingcondition)."}]
    背景
    别名
    IL-6, BSF2, HSF, IFNB2, IL-6, Interleukin-6
    背景

    Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans. Interleukin 6 was originally identified as a T cell-derived lymphokine that induces final maturation of B cells into antibody-producing cells. Recombinant human IL-6 acts on B cells activated with Staphylococcus aureus Cowan I or pokeweed mitogen (PWM) to induce immunoglobulin M (IgM), IgG and IgA production, but not on resting B cells. Anti-IL-6 antibody was found to inhibit PWM-induced Ig production, indicating that IL-6 is one of the essential factors in PWM-induced Ig production. Furthermore, IL-6 was shown to augment the primary and secondary anti-SRBC (sheep red blood cell) antibody production in mice in vivo.

    制备和贮存
    溶解方法
    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
    保存方式
    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
    文献
    文献

    1、Heinrich P C. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.

    2、Rose-John S. et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-624.

    3、Dinh W. et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

    数据库链接
    Accession
    P05231

    参考图片

    Measured in a cell proliferation assay using TF-1 cells, the EC50 for this effect is less than 0.2ng/ml.

    1μg (R:reducingcondition;N:non-reducingcondition).

    Protein A Chip captured IL-6R alpha/CD126 Fc Chimera, Human (Cat. No. UA010448), can bind IL-6, Human (Cat. No. UA040052) with an affinity constant of 8.51nM as determined in SPR assay.

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    货号：
    UA040052-100μg
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