Product Details

The 20C2 monoclonal antibody reacts with human interleukin-12 (IL-12), a heterodimeric 70 kDa (p70) cytokine consisting of two covalently linked subunits, 40 kDa (p40) and 35 kDa (p35). IL-12 is secreted by activated monocytes, macrophages, and dendritic cells in response to bacterial pathogens or products such as lipopolysaccharides (LPS). IL-12 is a potent regulator of cell-mediated immune responses and plays a key role in the development of Th1 responses, leading to IFNγ and IL-2 production.

Specifications

Isotype	Rat IgG1, κ
Recommended Isotype Control(s)	InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Partially purified human IL-12 p70
Reported Applications	Functional assays ELISA Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 µm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2687716
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

白细胞介素12蛋白抗体，磷酸盐缓冲液

应用

反应种属

human

背景

研究领域

Cytokine and Chemokine, Immunology

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货号：

BE0234-1MG

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