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产品介绍
产品信息
宿主
鼠
克隆号
MP2-8F8
克隆类别
单抗
Product Details
The MP2-8F8 monoclonal antibody reacts with mouse IL-3, a pleiotropic cytokine produced primarily by activated T cells but also by activated mast cells, keratinocytes and neurons/astrocytes. IL-3 is highly species-specific, mature human and mouse IL-3 share only 29% sequence identity and human IL-3 does not show activity on mouse cells. IL-3 can stimulate the proliferation and differentiation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. Additionally, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. The MP2-8F8 antibody has been reported to neutralize the bioactivity of natural or recombinant IL-3 as well as stimulate basophil proliferation when administered as a complex with IL-3.Specifications
| Isotype | Rat IgG1 |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase |
| Recommended Dilution Buffer | InVivoPure pH 6.5 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | COS-expressed, recombinant mouse IL-3 |
| Reported Applications | in vivo IL-3 neutralization in vitro IL-3 neutralization in vivo IL-3 receptor stimulation (as a complex with IL-3) ELISA Flow cytometry |
| Formulation | PBS, pH 6.5 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 μM filtered |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_2687805 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
多效细胞因子蛋白抗体，磷酸盐缓冲液
应用
反应种属
mouse
背景
研究领域
Cytokine and Chemokine, Immunology, Innate Immunity, Neuroscience
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危险品化学品经营许可证(不带存储) 许可证编号：沪(杨)应急管危经许[2022]202944(QY) 
营业执照(三证合一)