Product Details

The MP4-25D2 monoclonal antibody reacts with human IL-4 (interleukin-4) a multifunctional 14 kDa cytokine. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4Rα. Upon receptor binding IL-4 stimulates activated B and T lymphocyte proliferation, and the differentiation of B cells into plasma cells. It also induces B cell class switching to IgE, and up-regulates MHC class II production while decreasing the production of Th1 cells, macrophages, IFNγ, and dendritic cell IL-12. Like other Th2 associated cytokines, IL-4 is involved in the airway inflammation observed in the lungs of patients with allergic asthma. The MP4-25D2 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant human IL-4.

Specifications

Isotype	Rat IgG1, κ
Recommended Isotype Control(s)	InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Recombinant human IL-4 expressing CHO cells
Reported Applications	in vitro IL-4 neutralization Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 µm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2687722
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

白细胞介素4蛋白抗体，磷酸盐缓冲液

应用

反应种属

human

背景

研究领域

Cytokine and Chemokine, Immunology

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货号：

BE0240-1MG

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