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产品介绍
产品信息
宿主
鼠
克隆号
A7R34
克隆类别
单抗
Product Details
The A7R34 monoclonal antibody reacts with mouse IL-7Rα also known as CD127. IL-7Rα is a 60-90 kDa type I transmembrane glycoprotein expressed on immature B cells, thymocytes, peripheral T cells, and bone marrow stromal cells. IL-7Rα forms a heterodimer with the common γ chain (γc or CD132) and upon ligation of IL-7 plays important roles in T and B cell development, and T cell homeostasis. Thymic Stromal Lymphopoietin (TSLP) also binds to IL-7Rα as a complex with the TSLPR chain to trigger activation of dendritic cells, and is also involved in B cell development, allergy and autoimmunity. The A7R34 antibody has been shown to block IL-7Rα signaling when administered in vivo.Specifications
| Isotype | Rat IgG2a, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb rat IgG2a isotype control, anti-trinitrophenol |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | IL-7Rα-IgG1 fusion protein |
| Reported Applications | in vivo blocking of IL-7Rα signaling Flow cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_1107590 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
抗鼠IL-7Rα（I型跨膜蛋白）抗体，磷酸盐缓冲液
应用
反应种属
mouse
背景
研究领域
Apoptosis, Cancer Biology, Cytokine Receptor, Immunology, Neuroscience
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危险品化学品经营许可证(不带存储) 许可证编号：沪(杨)应急管危经许[2022]202944(QY) 
营业执照(三证合一)