Integrin alpha2 Antibody

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).Integrin alpha-2, also known as cluster of differentiation 49b, forms a heterodimer with integrin beta-1. This integral membrane receptor complex interacts with extracellular matrix molecules laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin (3-6). It can also act as a receptor for viral pathogens (7,8). Integrin alpha-2/beta-1 is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, and force generation and organization of newly synthesized extracellular matrix (3). 1.Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100. 2.Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71. 3.Adorno-Cruz, V. and Liu, H. (2019) Genes Dis 6, 16-24. 4.Languino, L.R. et al. (1989) J Cell Biol 109, 2455-62. 5.Yuan, Y. et al. (2016) Life Sci 149, 138-45. 6.Whittard, J.D. et al. (2002) Matrix Biol 21, 525-32. 7.Graham, K.L. et al. (2003) J Virol 77, 9969-78. 8.Bergelson, J.M. et al. (1993) J Virol 67, 6847-52.