Product Details

The HB220 antibody reacts with mouse CD45RB a 220 kDa transmembrane protein tyrosine phosphatase expressed on peripheral B cells naëâve T cells thymocytes and weakly on macrophages and dendritic cells. CD45RB is one of 5 isoforms of CD45 which result from alternative splicing of exons 4-6. CD45RB results from exon 5 splicing. CD45RB is critical for intracellular signaling in T cells in response to antigen stimulation as indicated by the severe immunodeficiency observed in CD45-deficient mice. As T cells progress from naëâve to memory cells and become activated CD45RB expression is downregulated. Additionally the intensity of CD45RB expression can be used to differentiate between functionally distinct CD4+ T cell subsets which secrete differing cytokine profiles. The primary ligands for CD45 include galectin-1 CD2 CD3 CD4 and Thy-1.

Specifications

Isotype	Rat IgG2a, κ
Recommended Isotype Control(s)	InVivoMAb rat IgG2a isotype control, anti-trinitrophenol
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Anti-immunoglobulin activated mouse B cells
Reported Applications	in vivo anti-CD45RB_mediated tolerance induction in vivo pre-mNK cell depletion
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 µm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_1107653
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

抗小鼠CD45RB抗体（抗220 kDa跨膜蛋白酪氨酸磷酸酶抗体）

应用

反应种属

mouse

背景

研究领域

Immunology, Innate Immunity

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

BE0019-1MG

一键复制

询价

1mg

5mg

25mg

50mg

100mg

选择数量

当前规格1件起购

配送至

预计2-3周送达，快递: 免运费，若需干冰额外收费

询价大包装询价