InVivoPlus anti-mouse IFNAR-1

InVivoPlus anti-mouse IFNAR-1

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品牌: BioXcell
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    反应种属:
    mouse
    mouse
    产品介绍
    产品信息
    克隆号
    MAR1-5A3
    克隆类别
    单抗

    Product Details

    The MAR1-5A3 monoclonal antibody reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). IFNAR-1 is coexpressed with IFNAR-2 on nearly all cell types and together these two subunits make up the heterodimeric Type I IFN Receptor complex. Type I IFNs (IFN-α/β) bind to the Type I IFN Receptor complex to induce cellular responses including induction of anti-viral, anti-microbial, anti-tumor, and autoimmune responses as well as to regulate the activation, proliferation, and differentiation of many cell types. The MAR1-5A3 antibody has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.

    Specifications

    Isotype Mouse IgG1, κ
    Recommended Isotype Control(s)InVivoPlus mouse IgG1 isotype control, unknown specificity
    Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
    Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
    Immunogen Extracellular domain of mouse IFNAR-1
    Reported Applicationsin vivo IFNAR-1 blockade
    in vitro IFNAR-1 blockade
    Western blot
    Formulation PBS, pH 7.0
    Contains no stabilizers or preservatives
    Endotoxin* <1EU/mg (<0.001EU/μg)
    Determined by LAL gel clotting assay
    Aggregation* <5%
    Determined by SEC
    Purity >95%
    Determined by SDS-PAGE
    Sterility 0.2 μM filtered
    Production Purified from cell culture supernatant in an animal-free facility
    Purification Protein G
    RRIDAB_2687723
    Molecular Weight 150 kDa
    Murine Pathogen Tests* Ectromelia/Mousepox Virus: Negative
    Hantavirus: Negative
    K Virus: Negative
    Lactate Dehydrogenase-Elevating Virus: Negative
    Lymphocytic Choriomeningitis virus: Negative
    Mouse Adenovirus: Negative
    Mouse Cytomegalovirus: Negative
    Mouse Hepatitis Virus: Negative
    Mouse Minute Virus: Negative
    Mouse Norovirus: Negative
    Mouse Parvovirus: Negative
    Mouse Rotavirus: Negative
    Mycoplasma Pulmonis: Negative
    Pneumonia Virus of Mice: Negative
    Polyoma Virus: Negative
    Reovirus Screen: Negative
    Sendai Virus: Negative
    Theiler’s Murine Encephalomyelitis: Negative
    Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
    * Additional quality control measures for our InVivoPlus™ products include advanced binding validation, murine pathogen screening, protein aggregation screening, and ultra-low endotoxin levels. The superior quality of our InVivoPlus™ products will meet and exceed the strict demands and rigorous standards required for in vivo research. Learn more about the InVivoPlus™ difference here.
    组成成分
    抗鼠干扰素α受体抗体,磷酸盐缓冲液
    应用
    反应种属
    mouse
    背景
    研究领域
    Cytokine Receptor, Immunology
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    货号:
    BP0241-5MG
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