

品牌: BD Pharmingen








反应种属:
Mouse (QC Testing)
Mouse (QC Testing)
来源宿主:
Rat IgG1, κ
Rat IgG1, κ
产品介绍
产品信息
耦联标记
Unconjugated

抗原名称
CD41 (Integrin α-IIb)

宿主
Rat IgG1, κ

免疫原
Mouse Platelets

简单描述
The MWReg30 monoclonal antibody specifically binds to CD41, which is also known as glycoprotein IIb (gpIIb, GP IIb), Integrin α IIb chain, or Integrin alpha 2b. CD41 is a transmembrane glycoprotein that is encoded by
Itga2b
. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

商品描述
The MWReg30 monoclonal antibody specifically binds to CD41, which is also known as glycoprotein IIb (gpIIb, GP IIb), Integrin α IIb chain, or Integrin alpha 2b. CD41 is a transmembrane glycoprotein that is encoded by
Itga2b
. CD41 associates with Integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis.
This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

同种型
Rat IgG1, κ

克隆号
MWReg30

浓度
0.5 mg/ml

产品详情
Purified
Tissue culture supernatant is purified by either protein A/G or affinity purification methods. Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. This format provides pure antibody that is suitable for a number of downstream applications including: secondary labeling for flow cytometry or microscopy, ELISA, Western blot, etc.
应用
实验应用
Flow cytometry (Routinely Tested) Immunohistochemistry-frozen, Inhibition, Depletion, Induction, Cytotoxicity, Immunoprecipitation (Reported)

反应种属
Mouse (QC Testing)

背景
别名
Itga2b; Integrin alpha 2b; Integrin alpha-IIb; Integrin α IIb; GpIIb

制备和贮存
存储溶液
Aqueous buffered solution containing ≤0.09% sodium azide.

保存方式
Aqueous buffered solution containing ≤0.09% sodium azide.
文献
文献
研发参考(5)
1. Bakewell SJ, Nestor P, Prasad S, et al. Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proc Natl Acad Sci U S A. 2003; 100(24):14205-14210. (Biology).
2. Ferkowicz MJ, Starr M, Xie X, et al. CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003; 130(18):4393-4403. (Biology).
3. Kieffer N, Phillips DR. Platelet membrane glycoproteins: functions in cellular interactions. Annu Rev Cell Biol. 1990; 6:329-357. (Clone-specific: Immunohistochemistry).
4. Nieswandt B, Echtenacher B, Wachs FP, et al. Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. Blood. 1999; 94(2):684-693. (Immunogen: Depletion, Immunohistochemistry, Immunoprecipitation, Induction).
5. Phillips DR, Charo IF, Scarborough RM. GPIIb-IIIa: the responsive integrin. Cell. 1991; 65(3):359-362. (Biology).

数据库链接
Entrez-Gene ID
16399

参考图片
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