CD11alpha (E5S9K) Rabbit mAb (BSA and Azide Free)

CD11α, also known as integrin alpha-L (ITGAL), is the alpha chain of the lymphocyte function-associated antigen-1 (LFA-1). CD11α combines with the beta chain CD18 (ITGB2) to form LFA-1, an integrin expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands ICAM-1, 2, 3, and 4 (1), F11R/JAM-1 (2,3), and the secreted form of ubiquitin-like protein ISG15 (4). LFA-1 is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction and transmigration (2,3), cytotoxic T cell co-stimulation (5), cytotoxic NK cell mediated killing (6), leukocyte clearance (7), and antibody-dependent killing by granulocytes and monocytes (8,9). LFA-1 is required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (10). High expression of CD11α has been associated with antigen-specific and tumor-reactive T cells (11,12). 1.Hynes, R.O. (1992) Cell 69, 11-25. 2.Ostermann, G. et al. (2002) Nat Immunol 3, 151-8. 3.Fraemohs, L. et al. (2004) J Immunol 173, 6259-64. 4.Swaim, C.D. et al. (2017) Mol Cell 68, 581-590.e5. 5.Ni, H.T. et al. (2001) J Immunol 166, 6523-9. 6.Barber, D.F. et al. (2004) J Immunol 173, 3653-9. 7.Kristóf, E. et al. (2013) Apoptosis 18, 1235-51. 8.Springer, T.A. et al. (1985) Adv Exp Med Biol 184, 311-22. 9.Kohl, S. et al. (1984) J Immunol 133, 2972-8. 10.Bose, T.O. et al. (2014) J Immunol 193, 2863-72. 11.Liu, X. et al. (2013) Oncoimmunology 2, e23972. 12.Christiaansen, A.F. et al. (2017) Vaccine 35, 4255-61.