BD Horizon™ BV711 Rat Anti-CD11b

BV711

CD11b (Integrin aM)

Rat DA, also known as DA/HA IgG2b, κ

Mouse Splenic Cells

The M1/70 monoclonal antibody specifically binds to CD11b, also known as Integrin alpha M (Itgam or αM). CD11b is a 170-kDa type 1 transmembrane glycoprotein and belongs to the Integrin alpha chain family. CD11b serves as the alpha chain of the heterodimeric Mac-1 integrin (CD11b/CD18, αMβ2), also known as complement receptor 3 (CR3). Mac-1 mediates adhesion to ICAM-1 (CD54), ICAM-2 (CD102), fibrinogen and binding to C3bi.  Mac-1 is expressed at varying levels on granulocytes, macrophages, myeloid-derived dendritic cells, natural killer cells, microglia, and B-1 B lymphocytes.  Mac-1 expression is rapidly upregulated on neutrophils after activation, in the same time period that CD62L (L-selectin) is shed from the cell surface.  The M1/70 antibody reportedly blocks cell adherence and C3bi binding but does not block cell-mediated lysis.  Cross-reaction of the M1/70 antibody with CD11b expressed on human monocytes, polymorphonuclear leukocytes, and NK cells has been reported.

Rat DA, also known as DA/HA IgG2b, κ

克隆 M1/70 (RUO)

0.2 mg/ml

Flow cytometry (Routinely Tested)

Mouse (QC Testing), Human (Tested in Development)

CD11b (Integrin αM)

Itgam; Integrin alpha-M; Ly-40; Mac-1a; Mac-1 alpha; CR3A; CR-3 alpha chain

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

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