SignalSilence ® Jak2 siRNA I

Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. 1.Leonard, W.J. and O'Shea, J.J. (1998) Annu Rev Immunol 16, 293-322. 2.Darnell, J.E. (1997) Science 277, 1630-5. 3.VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93. 4.Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92. 5.Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.