JSH-23

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JSH-23

品牌： Absin

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参数

分子式：

C₁₆H₂₀N₂

分子量：

240.34

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产品介绍

产品信息

抗原名称

NF-κB

商品描述

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC₅₀ of 7.1 μM.

分子量

240.34

纯度

>98%

可溶性

DMSO : 45 mg/mL (187.2 mM)
Ethanol ：16 mg/mL (66.6 mM)

外观

Off-white to gray-pink powder

In vitro(体外研究)

JSH-23 inhibits LPS-induced nuclear translocation of NF-κB p65 without affecting IκBα degradation. JSH-23 inhibits LPS-induced apoptotic chromatin condensation, while does not show significant cytotoxic effects on the RAW 264.7 cells at JSH-23 also decreases NO production and neuronal migration in LPS activated cultures primary cultures from developing mouse cerebellum. Moreover, JSH-23 augments cisplatin cytotoxicity in ovarian cancer cells with CI values ranging from 0.35 to 0.85.

In vivo(体内研究)

JSH-23 (3 mg/kg) significantly reverses the nerve conduction and nerve blood flow deficits by decreasing neuroinflammation and improving antioxidant defence in diabetic rats.

背景

分子式

C₁₆H₂₀N₂

CAS号

749886-87-1

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs810538-10mg

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