RSK1/RSK2/RSK3 (32D7) Rabbit mAb

The 90 kDa ribosomal S6 kinases (RSK1-4) are a family of widely expressed Ser/Thr kinases characterized by two nonidentical, functional kinase domains (1) and a carboxy-terminal docking site for extracellular signal-regulated kinases (ERKs) (2). Several sites both within and outside of the RSK kinase domain, including Ser380, Thr359, Ser363, and Thr573, are important for kinase activation (3). RSK1-3 are activated via coordinated phosphorylation by MAPKs, autophosphorylation, and phosphoinositide-3-OH kinase (PI3K) in response to many growth factors, polypeptide hormones, and neurotransmitters (3). 1.Fisher, T.L. and Blenis, J. (1996) Mol Cell Biol 16, 1212-9. 2.Smith, J.A. et al. (1999) J Biol Chem 274, 2893-8. 3.Dalby, K.N. et al. (1998) J Biol Chem 273, 1496-505.