SignalSilence ® TAK1 siRNA I

TAK1 is a mitogen-activated protein kinase kinase kinase that can be activated by TGF-β, bone morphogenetic protein and other cytokines including IL-1 (1,2). In vivo activation of TAK1 requires association with TAK1 binding protein 1 (TAB1), which triggers phosphorylation of TAK1 (3,4). Another adaptor protein, TAB2, links TAK1 with TRAF6 and mediates TAK1 activation upon IL-1 stimulation (5). Once activated, TAK1 phosphorylates MAPK kinases MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively. In addition, TAK1 activates the NF-κB pathway by interacting with TRAF6 and phosphorylating the NF-κB inducing kinase (NIK) (2). 1.Yamaguchi, K. et al. (1995) Science 270, 2008-11. 2.Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6. 3.Shibuya, H. et al. (1996) Science 272, 1179-82. 4.Sakurai, H. et al. (2000) FEBS Lett 474, 141-5. 5.Takaesu, G. et al. (2000) Mol Cell 5, 649-58.