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MAP2 (D5G1) XP ® Rabbit mAb
MAP2 (D5G1) XP ® Rabbit mAb

MAP2 (D5G1) XP ® Rabbit mAb

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品牌： CST
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    分子量：
    75, 82, 280
    75, 82, 280
    反应种属：
    Mouse,Rat,
    Mouse,Rat,
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    产品介绍
    产品信息
    抗原名称
    MAP2
    来源纯化
    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAP2 protein.
    宿主
    Rabbit
    简单描述
    Monoclonal Antibody for studying MAP2. Cited in 76 publications. Validated for WB, IP, IF. Available in 2 sizes. Highly specific and rigorously validated in-house, MAP2 (D5G1) XP® Rabbit Monoclonal Antibody (CST #8707) is ready to ship.
    商品描述

    Product Usage Information

    ApplicationDilution
    Western Blotting1:1000
    Immunoprecipitation1:50
    Immunofluorescence (Frozen)1:200
    分子量
    75, 82, 280
    内毒素水平
    人
    研究领域
    神经科学
    应用
    反应种属
    Mouse,Rat,
    预测反应种属
    Human
    目标/特异性

    Specificity/Sensitivity

    MAP2 (D5G1) XP® Rabbit mAb recognizes endogenous levels of total MAP2 protein. Non-specific labeling of mouse pancreas, colon, small intestine, and liver may be observed by immunofluorescence.

    Species Reactivity:

    Mouse, Rat

    敏感性
    Endogenous
    背景
    背景
    Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites (1). Multiple MAP2 isoforms are expressed in neurons, including high molecular weight MAP2A and MAP2B (280 and 270 kDa), and low molecular weight MAP2C and MAP2D (70 and 75 kDa). Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. GSK-3 and p44/42 MAP kinase phosphorylate MAP2 at Ser136, Thr1620, and Thr1623 (2,3). Phosphorylation at Thr1620/1623 by GSK-3 inhibits MAP2 association with microtubules and microtubule stability (3). 1.Sanchez, C. et al. (2000) Prog. Neurobiol. 61, 133-168. 2.Berling, B. et al. (1994) Eur. J. Cell Biol. 64, 120-130. 3.Sanchez, C. et al. (2000) Eur. J. Cell Biol. 79, 252-260.
    研究领域
    神经科学
    翻译后修饰
    Unmodified
    制备和贮存
    保存方式
    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product #65911.
    数据库链接
    Entrez-Gene ID
    4133
    UniProt ID
    P11137

    参考图片

    Confocal immunofluorescent analysis of frozen rat cerebellum using MAP2 (D5G1) XP® Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

    共聚焦免疫荧光分析冷冻大鼠小脑，使用的抗体是MAP2 (D5G1) XP® Rabbit mAb兔单抗（绿色）。蓝色伪彩=DRAQ5®＃4084（荧光DNA染料）。

    Western blot analysis of extracts from neonatal and adult mouse brain using MAP2 (D5G1) XP® Rabbit mAb.

    Western blot 检测新生和成年小鼠大脑提取物，使用的抗体是 MAP2 (D5G1) XP® Rabbit mAb兔单抗。

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    货号：
    8707T
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    20ul
    100ul
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    当前规格1件起购 
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