MAZ51

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MAZ51

品牌： Absin

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参数

分子式：

C₂₁H₁₈N₂O

分子量：

314.4

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产品介绍

产品信息

抗原名称

VEGFR3

商品描述

MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity.

分子量

314.4

纯度

≥98%

可溶性

DMSO : 8.33 mg/mL (26.50 mM; Need ultrasonic)

外观

orange solid

IC50

Flt-4: IC₅₀ = 1 µM; Ret: IC₅₀ = 45 µM (human)

In vitro(体外研究)

MAZ51 (2.5-10 μM; 24 hours) blocks proliferation and induces apoptosis in a wide variety of tumor cells.
MAZ51 (0.5-50 μM; 25 minutes) has no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ in A431 cells, HEK-293 cells, and PAE cells, respectively.

In vivo(体内研究)

MAZ51 (8 mg/kg; i.p.; daily for 15 day) significantly suppresses the growth of MT450 tumors.

背景

分子式

C₂₁H₁₈N₂O

CAS号

163655-37-6

PK值

pK_a: 12.78 (Predicted), pK_b: 4.42 (Predicted)

折射率

n²⁰_D 1.73 (Predicted)

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs819759-10mg

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