Methylene Blue

1/2

Methylene Blue

品牌： Absin

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参数

分子式：

C₁₆H₁₈ClN₃S

分子量：

319.85

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产品介绍

产品信息

抗原名称

guanylate cyclase；Tau aggregation

商品描述

Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.

分子量

319.85

纯度

97%

可溶性

DMSO ：63mg/mLwarming(196.96mM)
Water ：63mg/mLwarming(196.96mM)
Ethanol ：10mg/mLwarming(31.26mM)

In vitro(体外研究)

MB may inhibit the action of nitric oxide synthase itself and could also inactivate nitric oxide directly, possibly through the generation of superoxide anions. In addition to interfering with the nitric oxide–cyclic guanosine monophosphate pathway, MB has also been shown to directly activate calcium-dependent potassium channels and to enhance release of noradrenaline from intracellular stores.

In vivo(体内研究)

Methylene Blue acts by inhibiting guanylate cyclase, thus decreasing C-GMP and vascular smooth muscle relaxation. When injected intravenously, MB selectively accumulates in parathyroid glands, thereby facilitating the identification of these structures during surgery. Pharmacokinetic studies in rodents revealed that intravascular administration of MB leads to a rapid and extensive accumulation of this drug in the central nervous system (CNS).

背景

别名

亚甲兰；Basic Blue 9；Methylthioninium chloride；CI-52015

分子式

C₁₆H₁₈ClN₃S

CAS号

61-73-4

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs816058-100mg

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