MITF (D3B4T) Rabbit mAb

Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper transcription factor that is most widely known for its roles in melanocyte, ophthalmic, and osteoclast development (1-3). In humans, MITF can function as a melanoma oncogene (4) and mutations in the corresponding MITF gene are associated with Waardenburg syndrome type 2, an auditory-pigmentary syndrome characterized by developmental defects in cells derived from neural crest (5). At least 12 isoforms of MITF have been identified, which exhibit differential patterns of expression among cell and tissue types (6). 1.Hershey, C.L. and Fisher, D.E. (2004) Bone 34, 689-96. 2.Nomura, S. et al. (2001) J Bone Miner Metab 19, 183-7. 3.Widlund, H.R. and Fisher, D.E. (2003) Oncogene 22, 3035-41. 4.Levy, C. et al. (2006) Trends Mol Med 12, 406-14. 5.Read, A.P. and Newton, V.E. (1997) J Med Genet 34, 656-65. 6.Tachibana, M. (2000) Pigment Cell Res 13, 230-40.