MOG(1-125) Protein, Human

品牌： UA BIOSCIENCE

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参数

分子量：

20-23kDa (Reducing)

纯度：

>95% by SDS-PAGE

产品介绍

产品信息

耦联标记

Unconjugated

氨基酸序列

Gly30-Gly154, with C-terminal 8*His

分子量

20-23kDa (Reducing)

酶活定义

Female C57BL/6 mice (8-10 weeks old) were immunized with 100 ug/animal of human rMOG in complete Freund's adjuvant followed by 400 ng/mouse of pertussis toxin on day 0 and day 2. Mice showed EAE symptoms such as limp tail, hind limb weakness, or hind limb paralysis after induction. Please note that no other EAE induction protocols were tested including IFA/cytokine model.

纯度

>95% by SDS-PAGE

内毒素水平

<0.1EU/μg

性状

Lyophilized Powder

表达系统

HEK293

缓冲体系

PBS, pH7.4

标签

His Tag

种属

Human

电泳JSON

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背景

别名

MOG,BTN6,BTNL11,MOGIG2,NRCLP7,Myelin oligodendrocyte glycoprotein

背景

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily. Mouse MOG is synthesized with a 28 amino acid (aa) signal sequence, a 128 aa extracellular domain (ECD) containing an Ig-like domain, a 21 aa transmembrane domain, and a 69 aa cytosolic fragment featuring a hydrophobic domain that associates with the cytoplasmic face of the plasma membrane. MOG is expressed exclusively by oligodendrocytes in the central nervous system (CNS) and is localized to the outer layer of the myelin sheath as well as in the oligodendrocyte plasma membrane. This makes MOG a potential target of cellular and humoral immune responses in inflammatory demyelinating diseases.

制备和贮存

溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

保存方式

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

文献

1. Reindl, M. et al. (2013) Nat. Rev. Neurol. 9:455.

数据库链接

Accession

Q16653

参考图片

1μg (R: reducing conditions, N: non-reducing conditions).

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货号：

UA010471-100μg

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