Product Details

The C595 (also known as NCRC48) monoclonal antibody reacts with human mucin 1 (MUC1), a 500-1000 kDa transmembrane glycoprotein with a large mucin-like extracellular domain. The epitope of C595 is the tetrameric motif (RPAP) within the protein core of MUC1. MUC1 is highly polymorphic and is expressed on most mucosal epithelial cells, including mammary gland and some hematopoietic cells. MUC1 is heavily glycosylated and plays a crucial role in the lubrication and protection of normal epithelial cells. MUC1 is abnormally expressed in a wide variety of malignancies, including colon, breast, ovarian, lung and pancreatic cancers. MUC1 promotes cancer cell growth and metastases through multiple mechanisms. The C595 antibody has been shown to suppress ovarian tumor xenograft growth in mice.

Specifications

Isotype	Mouse IgG3, κ
Recommended Isotype Control(s)	InVivoMAb polyclonal mouse IgG
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Purified human MUC1
Reported Applications	in vivo administration in mouse xenograft models Immunohistochemistry (paraffin) Immunofluorescence in vitro cell cytotoxicity assay Western blot
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
RRID	AB_2894756
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

IGG-免疫球蛋白G型抗体

应用

反应种属

Human

背景

研究领域

Cancer Biology, Cell Migration & Adhesion, Tumor Antigens

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货号：

BE0336-1MG

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