NAC1 Antibody

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors (1,2). NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system (4). NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene (5,6). The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway (7). NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 (8). 1.Kalivas, P.W. et al. (1999) Synapse 33, 153-9. 2.Mackler, S.A. et al. (2000) J Neurosci 20, 6210-7. 3.Korutla, L. et al. (2005) J Neurochem 94, 786-93. 4.Korutla, L. et al. (2009) Neurochem Int 54, 245-52. 5.Nakayama, K. et al. (2006) Proc Natl Acad Sci USA 103, 18739-44. 6.Yeasmin, S. et al. (2008) Clin Cancer Res 14, 1686-91. 7.Jinawath, N. et al. (2009) Oncogene 28, 1941-8. 8.Kim, J. et al. (2008) Cell 132, 1049-61.