Necrostatin-34

品牌： Absin

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参数

分子式：

C18H16N4O2S2

CAS号：

375835-43-1

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产品介绍

产品信息

商品描述

Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.

纯度

98%

可溶性

DMSO:125 mg/mL (325.11 mM)

In vitro(体外研究)

Necrostatin-34 (10?μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation. Necrostatin-34 may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase. Necrostatin-34 shows IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively.

背景

分子式

C18H16N4O2S2

CAS号

375835-43-1

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs827994-1mg

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询价

1mg

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