NeuN (E4M5P) Mouse mAb

Neuronal nuclei (NeuN, Fox-3, RBFOX3) is a nuclear protein expressed in most post-mitotic neurons of the central and peripheral nervous systems. NeuN is not detected in Purkinje cells, sympathetic ganglion cells, Cajal-Retzius cells, INL retinal cells, inferior olivary, or dentate nucleus neurons (1). This neuronal protein was originally identified by immunoreactivity with a monoclonal antibody also called NeuN. Using MS-analysis, NeuN was later identified as the Fox-3 gene product. Fox-3 contains an RNA recognition motif and functions as a splicing regulator (2). Fox-3 regulates alternative splicing of NumB, promoting neuronal differentiation during development (3). 1.Mullen, R.J. et al. (1992) Development 116, 201-11. 2.Kim, K.K. et al. (2009) J Biol Chem 284, 31052-61. 3.Kim, K.K. et al. (2013) J Cell Biol 200, 443-58.