NS 19504 (10 mg)

727750

K_Ca1.1 (BK) channel activator

269.16

5-[(4-Bromophenyl)methyl]-2-thiazolamine

Selective activator of large-conductance Ca²⁺-activated potassium channels (BK_Ca, K_Ca1.1) (EC₅₀ = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K⁺ concentration or at 65 other receptors tested, including L- and N- type Ca²⁺ channels, Na_v, K_ATP and hERG channels.

≥99% (HPLC)

Soluble to 100 mM in DMSO and to 100 mM in ethanol

NC1=NC=C(CC2=CC=C(Br)C=C2)S1

C₁₀H₉BrN₂S

327062-46-4