


1/3
产品介绍
产品信息
分子量
16

背景
背景
Members of the INK4 family of cyclin-dependent kinase inhibitors include p16 INK4A, p15 INK4B, p18 INK4C, and p19 INK4D. The INK4 family members inhibit cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), causing cell cycle arrest in G1 phase. The INK4A-ARF-INK4B locus on chromosome 9p21, frequently lost in human cancer, encodes the INK4 family members p16 INK5A and p15 INK4B, as well as the unrelated protein, ARF (1).p16 INK4A expression, typically repressed in the absence of stress, is thought to drive cells into senescence, and p16 INK4A expression is a commonly used marker of senescent cells (2,3). p16 INK4A protein expression is often altered in human cancer, and high expression is currently used as a predictive biomarker in cervical cancer (3-5).
1.Kim, W.Y. and Sharpless, N.E. (2006) Cell 127, 265-75.
2.LaPak, K.M. and Burd, C.E. (2014) Mol Cancer Res 12, 167-83.
3.Romagosa, C. et al. (2011) Oncogene 30, 2087-97.
4.Ishikawa, M. et al. (2006) Int J Gynecol Cancer 16, 347-53.
5.Queiroz, C. et al. (2006) Pathol Res Pract 202, 77-83.

研究领域
癌症,细胞生物学,
声明 :本官网所有报价均为常温或者蓝冰运输价格,如有产品需要干冰运输,需另外加收干冰运输费。