PACAP 6-38 (100 ug)

24868185

FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK

(Modifications: Lys-33 = C-terminal amide)

Potent PAC₁ receptor antagonist

4024.78

Potent and competitive pituitary adenylate cyclase-activating polypeptide receptor (PAC)₁ antagonist (IC₅₀ = 2 nM). Inhibits PACAP(1-27)-induced stimulation of adenylate cyclase (K_i = 1.5 nM). Antitumor activity in vivo.

≥95% (HPLC)

Soluble to 2 mg/ml in water

[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC

C₁₈₂H₃₀₀N₅₆O₄₅S

143748-18-9