Pbx 1/2/3/4 (E-12)

mouse

Pbx 1/2/3/4抗体(E-12)是小鼠单克隆IgG1 (kappa轻链)，规格为200 µg/ml 免疫human来源Pbx 1位于N-terminus 的1-260氨基酸 推荐用于 mouse, rat 和 human 来源的Pbx 1, Pbx 2, Pbx 3 and Pbx 4 WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： 和 canine, bovine and porcine m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Pbx 1/2/3/4 Antibody (E-12) for WB 的首选应用二抗。这些试剂现在以套装形式提供Pbx 1/2/3/4 Antibody (E-12)。 (见下方订购信息). Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Replacement monoclonal antibody for: sc-25411, sc-889, sc-888.

IGG-免疫球蛋白G型抗体

MousePbx3

WB, IP, IF, ELISA

5087, 5089, 5090, 80714;18514, 18515, 18516, 80720