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This antibody recognizes the same epitope as clone RMP1-14.
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
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2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
参考图片
Anti-His antibody Immobilized on CM5 Chip captured PD1 His Tag, Mouse, can bind PD-1 Recombinant Mouse mAb (RMP1-14) with an affinity constant of 0.195 nM as determined in SPR assay.
Anti-tumor efficacy of S0B0594 in B16-OVA tumor-bearing mice