Invivo anti-mouse PD-1 Recombinant mAb (D265A)
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Invivo anti-mouse PD-1 Recombinant mAb (D265A)

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品牌: STARTER
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    反应种属:
    Ms
    Ms
    来源宿主:
    Mouse
    Mouse
    展开
    产品介绍
    产品信息
    耦联标记
    Unconjugated
    纯化方式
    Protein G
    抗原名称
    PD-1
    宿主
    Mouse
    同种型
    Mouse IgG1 D265A, κ
    克隆号
    S-5001
    内毒素水平
    <1EU/mg
    浓度
    Lot specific* (generally 5 to 20 mg/ml)*
    性状
    Liquid
    缓冲体系
    PBS pH7.4, containing no preservative
    产品类型
    Recombinant mAb
    应用
    实验应用
    In vivo blocking of PD-1/PD-L signaling
    反应种属
    Ms
    背景
    别名
    Programmed cell death protein 1, mPD-1, CD279
    背景

    This antibody recognizes the same epitope as clone RMP1-14.

    Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).

    细胞定位
    Cell membrane
    制备和贮存
    保存方式

    2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.

    数据库链接
    Accession

    参考图片

    Anti-His antibody Immobilized on CM5 Chip captured PD1 His Tag, Mouse, can bind PD-1 Recombinant Mouse mAb (RMP1-14) with an affinity constant of 0.195 nM as determined in SPR assay.

    Anti-tumor efficacy of S0B0594 in B16-OVA tumor-bearing mice

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    货号:
    S0B0594-1mg
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