CD31 (PECAM-1) (D8V9E) XP ®  Rabbit mAb

CD31 (PECAM-1) (D8V9E) XP ® Rabbit mAb

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品牌: CST
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    分子量:
    135
    135
    反应种属:
    Mouse
    Mouse
    展开
    产品介绍
    产品信息
    抗原名称
    CD31
    来源纯化
    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala451 of mouse CD31 (PECAM-1) protein.
    宿主
    Rabbit
    简单描述
    Monoclonal Antibody for studying PECAM-1. Cited in 237 publications. Validated for WB, IHC, IHC. Available in 2 sizes. Highly specific and rigorously validated in-house, CD31 (PECAM-1) (D8V9E) XP® Rabbit Monoclonal Antibody (CST #77699) is ready to ship.
    商品描述

    Product Usage Information

    ApplicationDilution
    Western Blotting1:1000
    IHC Leica Bond1:50 - 1:200
    Immunohistochemistry (Paraffin)1:50 - 1:200
    分子量
    135
    研究领域
    癌症,纤维化,免疫学和肿瘤学,神经科学,
    应用
    反应种属
    Mouse
    目标/特异性

    Specificity/Sensitivity

    CD31 (PECAM-1) (D8V9E) XP® Rabbit mAb recognizes endogenous levels of total CD31 (PECAM-1) protein.

    Species Reactivity:

    Mouse

    敏感性
    Endogenous
    背景
    背景
    CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3). 1.Newman, P.J. (1997) J. Clin. Invest. 99, 3-8. 2.Cao, M. Y. et al. (1998) J. Biol. Chem. 273, 15765-72. 3.Ilan, N. and Madri, J.A. (2003) Curr. Opin. Cell Biol. 15, 515-24.
    研究领域
    癌症,纤维化,免疫学和肿瘤学,神经科学,
    翻译后修饰
    Unmodified
    制备和贮存
    保存方式
    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #92841.
    数据库链接
    Entrez-Gene ID
    5175
    UniProt ID
    P16284

    参考图片

    Immunohistochemical analysis of paraffin-embedded A2058 xenograft using CD31 (PECAM-1) (D8V9E) XP® Rabbit mAb.

    Immunohistochemical analysis of paraffin-embedded mouse liver using CD31 (PECAM-1) (D8V9E) XP® Rabbit mAb.

    Immunohistochemical analysis of paraffin-embedded mouse kidney using CD31 (PECAM-1) (D8V9E) XP® Rabbit mAb.

    Western blot analysis of extracts from 32D (CD31/PECAM-1 positive) and 3T3 (CD31/PECAM-1 negative) cells using CD31 (PECAM-1) (D8V9E) XP® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

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    货号:
    77699T
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    20ul
    100ul
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    当前规格1件起购 
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