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Presenilin 1 (D39D1) Rabbit mAb

品牌： CST

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参数

分子量：

22 (CTF)

反应种属：

Human,Mouse,Rat,Monkey,

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产品介绍

产品信息

抗原名称

Presenilin 1

来源纯化

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human Presenilin 1 protein.

宿主

Rabbit

简单描述

Monoclonal Antibody for studying Presenilin-1. Cited in 67 publications. Validated for Western Blotting, Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Presenilin 1 (D39D1) Rabbit Monoclonal Antibody (CST #5643) is ready to ship.

商品描述

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

分子量

22 (CTF)

研究领域

神经科学

应用

反应种属

Human,Mouse,Rat,Monkey,

目标/特异性

Specificity/Sensitivity

Presenilin 1 (D39D1) Rabbit mAb recognizes endogenous levels of total Presenilin 1 protein. The antibody may detect a nonspecific band at 60 kDa.

Species Reactivity:

Human, Mouse, Rat, Monkey

敏感性

Endogenous

背景

Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilin's associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3). 1.Haass, C. and De Strooper, B. (1999) Science 286, 916-9. 2.Kimberly, W.T. et al. (2000) J. Biol. Chem. 275, 3173-3178. 3.Kim, T.W. et al. (1997) J. Biol. Chem. 272, 11006-11010.

研究领域

神经科学

翻译后修饰

Unmodified

制备和贮存

保存方式

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

数据库链接

Entrez-Gene ID

5663

UniProt ID

P49768

参考图片

Western blot analysis of extracts from HeLa, wild-type MEF, and Presenilin 1(-/-) MEF cells using Presenilin 1 (D39D1) Rabbit mAb (upper) and α/β-Tubulin Antibody #2148 (lower). (Wild-type MEF and Presenilin 1(-/-) MEF cells were kindly provided by Dr. Bart De Strooper, K.U.Leuven, Belgium).

Western blot分析HeLa、野生型和Presenilin 1(-/-) 突变型MEF细胞提取物，使用的抗体是Presenilin 1 (D39D1) Rabbit mAb 兔单抗（上图）及α/β-Tubulin Antibody 兔多抗#2148（下图）。（野生型MEF和Presenilin 1(-/-) 突变型MEF细胞由Dr.Bart De Strooper, K.U.Leuven, Belgium友情提供）。

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货号：

5643T

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供应商现货

20ul

100ul

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