Anti-KCNH6 (erg2) Antibody

K_v11.2 (erg2) is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K+ channels. The erg subfamily includes the closely related proteins K_v11.1 (erg1) and K_v11.3 (erg3) that possess the signature structure of the voltage-dependent K⁺ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K⁺ channels, the functional channel is a tetramer composed of four subunits. It has been suggested that the K_v11 subfamily members can form functional heteromultimers within the subfamily.

K_v11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel K_v11.1.

The expression of K_v11.2 seems to be limited to the brain and the pituitary gland. The same is true for the K_v11.3 protein, while K_v11.1 is more widely expressed. 

From a pharmacological point of view, K_v11.2 channels can be blocked by well characterized organic blockers such as the anti-arrhythmic drug E-4031 (#E-500). In addition, the peptide toxins Ergtoxin-1 (#RTE-450) and BeKm-1 (#RTB-470), block K_v11.2 with different potencies.