BD Pharmingen™ APC-Cy™7 Mouse Anti-Human CD45

APC-Cy7

CD45

Mouse IgG1, κ

The 2D1 monoclonal antibody recognizes an epitope on all forms of CD45, a tyrosine phosphatase. CD45 is a type I transmembrane glycoprotein that belongs to the Protein Tyrosine Phosphatase (PTP) family. There are several isoforms of CD45 with molecular weights ranging from 180 to 220 kDa. CD45 is expressed on all nucleated cells of hematopoietic origin and is also known as the Leukocyte Common Antigen (LCA). CD45 is most highly expressed on lymphocytes and multiple CD45 isoforms can be coexpressed on individual leucocytes. CD45 plays an important role in regulating leucocyte functions by modifying other signaling molecules.

The 2D1 monoclonal antibody recognizes an epitope on all forms of CD45, a tyrosine phosphatase. CD45 is a type I transmembrane glycoprotein that belongs to the Protein Tyrosine Phosphatase (PTP) family. There are several isoforms of CD45 with molecular weights ranging from 180 to 220 kDa. CD45 is expressed on all nucleated cells of hematopoietic origin and is also known as the Leukocyte Common Antigen (LCA). CD45 is most highly expressed on lymphocytes and multiple CD45 isoforms can be coexpressed on individual leucocytes. CD45 plays an important role in regulating leucocyte functions by modifying other signaling molecules.

Mouse IgG1, κ

克隆 2D1 (RUO)

Flow cytometry (Routinely Tested)

5 µl

Human (QC Testing)

CD45

PTPRC; LCA; L-CA; Leukocyte Common Antigen; T200; GP180; LY5

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

研发参考(4) 1. Beavis AJ, Pennline KJ. Allo-7: a new fluorescent tandem dye for use in flow cytometry. Cytometry. 1996; 24(4):390-395. (Biology). 2. Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:1-1182. 3. Roederer M, Kantor AB, Parks DR, Herzenberg LA. Cy7PE and Cy7APC: bright new probes for immunofluorescence. Cytometry. 1996; 24(3):191-197. (Biology). 4. Terry LA, Brown MH, Beverley PC. The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45. Immunology. 1988; 64(2):331-336. (Biology).