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RecombiMAb anti-mouse Ly6G
RecombiMAb anti-mouse Ly6G
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RecombiMAb anti-mouse Ly6G

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品牌： BioXcell
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    来源宿主：
    鼠
    鼠
    产品介绍
    产品信息
    宿主
    鼠
    克隆号
    1A8-CP129

    Product Details

    The 1A8-CP129 monoclonal antibody is a chimeric version of the original 1A8 antibody. The variable domain sequences are identical to the original 1A8 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. The 1A8-CP129 antibody contains no Fc mutations just as the original rat IgG2a antibody does not. The 1A8-CP129 monoclonal antibody reacts with mouse Ly6G. Ly6G is a 21-25 kDa member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Ly6G is expressed differentially during development by cells in the myeloid lineage including monocytes, macrophages, granulocytes, and neutrophils. Monocytes typically express Ly6G transiently during development while mature granulocytes and peripheral neutrophils retain expression making Ly6G a good cell surface marker for these populations. Unlike the RB6-8C5 antibody, the 1A8-CP129 antibody reacts specifically with mouse Ly6G with no reported cross reactivity with Ly6C.

    Specifications

    Isotype Mouse IgG2a, κ
    Recommended Isotype Control(s)InVivoPlus mouse IgG2a isotype control, unknown specificity
    Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
    Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
    Immunogen EL4J cells transfected with Ly6G
    Reported Applicationsin vivo neutrophil depletion*
    in vivo MDSC depletion*
    Immunofluorescence*
    Immunohistochemistry (paraffin)*
    Immunohistochemistry (frozen)*
    Flow cytometry*
    *Reported for the original rat IgG2a 1A8 antibody
    Formulation PBS, pH 7.0
    Contains no stabilizers or preservatives
    Endotoxin <1EU/mg (<0.001EU/μg)
    Determined by LAL gel clotting assay
    Aggregation <5%
    Determined by SEC
    Purity >95%
    Determined by SDS-PAGE
    Sterility 0.2 µm filtration
    Production Purified from CHO cell supernatant in an animal-free facility
    Purification Protein G
    Molecular Weight 150 kDa
    Murine Pathogen Tests Ectromelia/Mousepox Virus: Negative
    Hantavirus: Negative
    K Virus: Negative
    Lactate Dehydrogenase-Elevating Virus: Negative
    Lymphocytic Choriomeningitis virus: Negative
    Mouse Adenovirus: Negative
    Mouse Cytomegalovirus: Negative
    Mouse Hepatitis Virus: Negative
    Mouse Minute Virus: Negative
    Mouse Norovirus: Negative
    Mouse Parvovirus: Negative
    Mouse Rotavirus: Negative
    Mycoplasma Pulmonis: Negative
    Pneumonia Virus of Mice: Negative
    Polyoma Virus: Negative
    Reovirus Screen: Negative
    Sendai Virus: Negative
    Theiler’s Murine Encephalomyelitis: Negative
    Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
    组成成分
    锚定细胞表面蛋白抗体，磷酸盐缓冲液
    背景
    研究领域
    Cancer Biology, Immunology, Innate Immunity
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    货号：
    CP129-1MG
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