Resiquimod

1/2

Resiquimod

品牌： Absin

下载产品说明书

用小程序，查商品更便捷

对比

咨询

参数

分子式：

C₁₇H₂₂N₄O₂

分子量：

314.38

展开

产品介绍

产品信息

抗原名称

TLR7；TLR8

商品描述

Resiquimod (R-848; S28463) is a potent synthetic agonist of TLR7/TLR8 that possesses antiviral and antitumoral activities.

分子量

314.38

纯度

>98%

可溶性

DMSO ：63 mg/mL (200.39 mM)
Ethanol ：21 mg/mL warmed (66.79 mM)

外观

white to tan powder

In vitro(体外研究)

Resiquimod activates immune cells and induces proliferation of wild-type splenocytes via the Toll-like receptor 7 (TLR7)-MyD88-dependent signaling pathway. Resiquimod also modulates dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. Resiquimod induces the differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, and may improve cancer immunotherapy by reducing immunosuppressive MDSCs.

In vivo(体内研究)

In wild-type mice, Resiquimod (50 nmol, i.p.) induces increased serum concentrations of IFN-alpha, TNF-alpha and IL-12, while neither TLR7-deficient mice nor MyD88-deficient mice show an increase in these cytokines. In a murine model of allergic asthma, Resiquimod (i.n., 20 μg/mouse) reduces allergen induced airway reactivity and inflammation via reduction in Nrf2 signaling.

背景

别名

雷西莫特；瑞喹莫德

分子式

C₁₇H₂₂N₄O₂

CAS号

144875-48-9

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

参考图片

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

abs810694-5mg

一键复制

询价

优宁维现货

5mg

10mg

50mg

100mg

选择数量

当前规格1件起购

配送至

预计2-5个工作日送达，快递: 免运费，若需干冰额外收费

询价大包装询价