RNF212

Recombinant human Probable E3 SUMO-protein ligase RNF212 V protein (aa1-297)

Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).

IgG

Polyclonal

Purified by immunoaffinity chromatography.

Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.

Western Blot: 1:200-1000 Immunohistochemistry: 1:20-1:200 Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Human

RING finger protein 212,RNF212

Q495C1