ROBO4 His Tag Protein, Mouse

ROBO4 His Tag Protein, Mouse

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    分子量:
    60-75kDa (Reducing)
    60-75kDa (Reducing)
    纯度:
    >95% by SDS-PAGE
    >95% by SDS-PAGE
    产品介绍
    产品信息
    耦联标记
    Unconjugated
    氨基酸序列

    Leu28-Glu470, with C-terminal 8*His

    LDSPPQILVHPQDQLLQGSGPAKMRCRSSGQPPPTIRWLLNGQPLSMATPDLHYLLPDGTLLLHRPSVQGRPQDDQNILSAILGVYTCEASNRLGTAVSRGARLSVAVLQEDFQIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQPGRRTVSGDSLMVSRAEKNDSGTYMCMATNNAGQRESRAARVSIQESQDHKEHLELLAVRIQLENVTLLNPEPVKGPKPGPSVWLSWKVSGPAAPAESYTALFRTQRSPRDQGSPWTEVLLRGLQSAKLGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQVPSAPPQGVTLRSGNGSVFVSWAPPPAESHNGVIRGYQVWSLGNASLPAANWTVVGEQTQLEIATRLPGSYCVQVAAVTGAGAGELSTPVCLLLEQAMEQSARDPRKHVPWTLEQLRATLRRPEGGGSHHHHHHHH

    分子量
    60-75kDa (Reducing)
    纯度
    >95% by SDS-PAGE
    内毒素水平
    <0.1EU/μg
    性状
    Lyophilized Powder
    表达系统
    HEK293
    缓冲体系
    PBS, pH7.4
    标签
    His Tag
    种属
    Mouse
    电泳JSON
    [{"imgUrl":"https://univ-pmc.oss-cn-shanghai.aliyuncs.com/product.imager.attribute/0/25b104a3-527d-4bf9-b6ab-28750cb18ad1.png","description":"1μg (R: reducing condition, N: non-reducing condition)."}]
    背景
    别名
    roundabout, axon guidance receptor, homolog 4 (Drosophila)
    背景

    Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family.Roundabout 4 (Robo4) is a transmembrane receptor that expresses specifically in endothelial cells. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains.     ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker.  ADAM10 and ADAM17 are abscisic enzymes of Robo4, and the negative regulation of their ligand Slit3 is a new control mechanism of Robo4 signaling in angiogenesis.


    制备和贮存
    保存方式

    ·12 months from date of receipt, -20 to -70 °C as supplied. 

    ·1 month, 2 to 8 °C under sterile conditions after reconstitution.  

    ·Please avoid repeated freeze-thaw cycles.


    文献
    文献

    1.Xiao, W., Pinilla-Baquero, A., Faulkner, J. etal. Robo4 is constitutively shed by ADAMs from endothelial cells and the shedRobo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep 12, 4352 (2022).https://doi.org/10.1038/s41598-022-08227-8.

    数据库链接
    Accession

    参考图片

    1μg (R: reducing condition, N: non-reducing condition).

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    货号:
    UA010455-100ug
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