RSL3

1/3

RSL3

品牌： Absin

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参数

分子式：

C₂₃H₂₁ClN₂O₅

分子量：

440.88

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产品介绍

产品信息

抗原名称

Gpx4

商品描述

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis.

分子量

440.88

纯度

＞98%

可溶性

DMSO : ≥ 31 mg/mL (70.31 mM)

外观

白色或类白色固体

In vitro(体外研究)

Ferroptosis-inducing compounds inactivate GPX4 by direct binding or by depleting glutathione.After binding to GPX4, RSL3 inactivates GPX4 to induce ROS production from lipid peroxidation. RSL3's ability to induce synthetic lethality with oncogenic RAS is rapid and quite potent. This compound inhibits the growth of BJ-TERT/LT/ST/RASV12 and DRD cells as low as 10 ng/mland started to kill sensitive cells as early as 8 hr after treatment.

In vivo(体内研究)

Prostaglandin-endoperoxide synthase (PTGS) is the key enzyme in prostaglandin biosynthesis. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2. PTGS2 encoding cyclooxygenase-2 (COX-2) is significantly upregulated after treatment with RSL3 and erastin in mice.

背景

别名

RSL3 1S,3R-；1S,3R-RSL3

分子式

C₂₃H₂₁ClN₂O₅

CAS号

1219810-16-8

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs816204-5mg

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