S100A12

Recombinant human Protein S100-A12 (1-92aa)

Suitable for use in ELISA. Other applications not tested.

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

IgG

Polyclonal

Purified by immunoaffinity chromatography.

Suitable for use in ELISA. Other applications not tested.

Optimal dilutions to be determined by the researcher.

Rabbit

Hu

Human

CGRP,Calcium-binding protein in amniotic fluid 1,CAAF1,Calgranulin-C,CAGC,Extracellular newly identified RAGE-binding protein,EN-RAGE,Migration inhibitory factor-related protein 6,MRP-6,Neutrophil S100 protein,S100 calcium-binding protein A12,S100A12

P80511