SB 431542 (1 mg)

4521392

Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7

384.39

4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Potent antagonist for α7-containing neuronal nicotinic receptors (K_i = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.

≥99% (HPLC)

Soluble to 100 mM in water and to 100 mM in DMSO

NC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=N1)C1=CC2=C(OCO2)C=C1

C₂₂H₁₆N₄O₃

301836-41-9